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what is the relative response factor in related substances?
is it necessary to calculate?
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Answer Posted / sree
respone factor of impurity = responese of impurity/reponse
of active peak pertaining to paricular detection
suppose for detection by uv detector reponse of peak is
equals to area of peak/concentration
impurities (structures having more conjugation ) have more
response factor to active peak
it is necessary to normalise all response of impurities
with respect to active peak at particular detection.
hence response factor used for calculation for detemination
of absolute percentage in druf product or drug substances
RELATIVE RESPONSE FACTOR= /RESPONSE FACTOR
CAN BE DETERMINED BY LINARITY OF ACTIVE AND IMPURITY AT
VARIOUS LEVLES
RESPONSE FACTOR -SLOPE OF CALIBARION CURVE OF
IMPURITY /ACTIVE
| Is This Answer Correct ? | 27 Yes | 4 No |
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