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Difference Between Purity And Potency?
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purity is the absence of impurities or contaminants in a substance
potency is the term used to express the effect of drug.potency is the amount of drug required to show effect of given intensity
highly potent drugs shows a larger effect at low concentrations .
potency of a drug directly proportional to purity
| Is This Answer Correct ? | 29 Yes | 4 No |
Answer / navinpatel
Potency is a measure of drug activity expressed in terms of
the amount of drug required to produce an effect
(Physiological, Therapeutical, Inhibitor) of given
intensity. A highly potent drug (e.g., morphine) produce a
greater response at low concentrations, while a drug of
lower potency (ibuprofen, acetylsalicylic acid) produce a
small response at low concentrations.
Purity is the absence of unwanted substance either impurity
or contaminants. Purity is one of the most important
parameters considered in pharmaceutical products. More pure
the substance more is the activity.
| Is This Answer Correct ? | 9 Yes | 0 No |
Answer / naveen gutta
Purity:
It is calculated by area normalisation method, it can be directly find out by chromatograms obtained from HPLC.
% Purity = (Area of desired peak / Sum of area of all peaks) x 100
Assay:
It is calculated against standard. It may be of following types:
1) On as is basis = (Area of sample / Area of standard) x (conc. of standard / conc. of sample) x potency or assay of standard
2) On anhydrous basis = (Assay on as is basis / 100 – moisture) x 100
3) On dried basis = (Assay on as is basis / 100 – LOD) x 100
Potency:
100 – (moisture or LOD + residual solvents + heavy metals + sulphated ash + impurities)
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