Some of the advantages of protoplast fusion are

large scale reproducible isolation of protoplasts from
various tissues and more or less universal application;

osmotic shrinkage is minimum and the deleterious effects of
excessive plasmolysis are minimized;

cells remain intact and are not injured as is the case of
mechanical methods of isolation; and

protoplasts are readily obtained.

it can produce a good hybrid plants like disease
resistance,virus resistance,delay ripening of fruits,etc.

can combing distant related parental plant
can obtain highyielding plants.
can prodiuce disease resistant plant
can prodiuce high responsible plant for fertilizer 
can prodiuce plant for suitabal to various claimate (short 
plant resistant to wind)