Validation in the pharmaceutical and medical device
industry is defined as the documented act of demonstrating
that a procedure, process, and activity will consistently
lead to the expected results.
Making measurements with any analytical method or
instrument requires calibration to ensure the accuracy of
the measurement. There are two common calibration
procedures: using a working curve, and the standard-
addition method. Both of these methods require one or more
standards of known composition to calibrate the
Validation mean documented evidence that a particular
instrument or process produce results meet predetermined
Calibration means particular instrument or device produce
results by comparison of known reference standard.
Calibration is done to nulify or remove the deviation by comparing with known or reference standard,
while Validation is done to prove that Consistency of expacted results of Process,Method,or Procedure
will calibratin only for instruments ,. but we can perform
validation not only for instuments for method allso,,..
calibratiom = checking the instrument with standards
validation = validating the existing method or instrument