Relative to polymer chains, the difference between
configuration and conformation is that conformation is used
in reference to the outline or shape of the chain molecule,
whereas, configuration refers to the arrangement of atom
positions along the chain that are not alterable except by
the breaking and reforming of primary bonds.
. Configuration refers to the order that is determined by
chemical bonds. The configuration of a molecule cannot be
altered unless chemical bonds are broken and reformed.
Conformation refers to order that arises from the rotation
of molecules about the single bonds. Free rotation around a
C-C single bond of an organic molecule gives conformations
It refers to the absolute arrangement of atoms or substituent groups in space around the atom. Configurational isomers cannot be interconverted without the breaking of one or more covalent bonds.
It refers to the 3 dimensional arrangement of group of atoms that can be altered without breaking any covalent bonds. Rotation around single bonds allows the molecule to undergo transition between conformers.