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Categories >> Sciences >> Health Pharma >> Lab Technicians
 
 


 

 
 Pharmacy interview questions  Pharmacy Interview Questions (220)
 Lab Technicians interview questions  Lab Technicians Interview Questions (73)
 Health Pharma AllOther interview questions  Health Pharma AllOther Interview Questions (82)
Question
what is the relative response factor in related substances?

 is it necessary to calculate?
 Question Submitted By :: Lab-Technicians
I also faced this Question!!     Answer Posted By  
 
Answer
# 1
Definition of relative response factor :
A measure of the relative response of the instrument
detector to an analyte compared to an internal or external
standard. Relative Response Factors are determined by the
analysis of standards and are used to calculate the
concentrations of analytes in samples. The RRF can be
calculated using the following equation:

RRF = (Ac x Cis)/(Ais x Cc)

where,
RRF = Relative response factor
Ac = Area of the target analyte
Ais = Area of the corresponding internal standard
Cis = Concentration of the corresponding internal standard
Cc = Concentration of the target analyte
 
Is This Answer Correct ?    25 Yes 1 No
Subhashini
 
Answer
# 2
respone factor of impurity = responese of impurity/reponse
of active peak pertaining to paricular detection

suppose for detection by uv detector reponse of peak is
equals to area of peak/concentration

impurities (structures having more conjugation ) have more
response factor to active peak

it is necessary to normalise all response of impurities
with respect to active peak at particular detection.
hence response factor used for calculation for detemination
of absolute percentage in druf product or drug substances


RELATIVE RESPONSE FACTOR= /RESPONSE FACTOR
CAN BE DETERMINED BY LINARITY OF ACTIVE AND IMPURITY AT
VARIOUS LEVLES

RESPONSE FACTOR -SLOPE OF CALIBARION CURVE OF
IMPURITY /ACTIVE
 
Is This Answer Correct ?    25 Yes 4 No
Sree
 
 
 
Answer
# 3
Response factor = response(in response units)
concentration(in mg/mL)
Relative response factor: the ratio of the response
factor of individual related
substance to that of a drug substance to correct for
differences in the response
of related substances and that of the drug substance. It
can be determined using the following equation:
Relative response factor = response factor of individual
related substance
response factor of drug substance
If a linearity curve is constructed for both the related
substance
and the drug substance by plotting the response versus the
concentration,
the relative response factor can also be determined by
Relative response factor = sloperelated substance
slopedrug substance

The relative response factor (RRF) can be used to
correct for differences in relative response between the
related substances and
the drug substance.
 
Is This Answer Correct ?    17 Yes 1 No
Prashant Dhuri
 
Answer
# 4
HOW METHOD DEVELOP FOR RELATED SUBSTANCE IN PHARMACEUTICAL
DRUG PRODUCTS.
 
Is This Answer Correct ?    13 Yes 8 No
Dipak
 
Answer
# 5
A measure of the relative response of the instrument
detector to an analyte compared to an internal or external
standard. Relative Response Factors are determined by the
analysis of standards and are used to calculate the
concentrations of analytes in samples. The RRF can be
calculated using the following equation:

RRF = (Ac x Cis)/(Ais x Cc)

where,
RRF = Relative response factor
Ac = Area of the target analyte
Ais = Area of the corresponding internal standard
Cis = Concentration of the corresponding internal standard
Cc = Concentration of the target analyte
 
Is This Answer Correct ?    2 Yes 1 No
Krishna Vakharia
 
Answer
# 6
Definition of relative response factor :
A measure of the relative response of the instrument
detector to an analyte compared to an internal or external
standard. Relative Response Factors are determined by the
analysis of standards and are used to calculate the
concentrations of analytes in samples. The RRF can be
calculated using the following equation:

RRF = (Ac x Cis)/(Ais x Cc)

where,
RRF = Relative response factor
Ac = Area of the target analyte
Ais = Area of the corresponding internal standard
Cis = Concentration of the corresponding internal standard
Cc = Concentration of the target analyte
 
Is This Answer Correct ?    2 Yes 1 No
Krishna Vakharia
 
Answer
# 7
How to calculated RRF .and why 
Is This Answer Correct ?    0 Yes 0 No
Ajay Maurya
 
Answer
# 8
1.To correct detetor respone in impurity profile and drug
subatance.
2. used in stability indicating method
3. used in phase-1 to phase -4 study
4. used in cost reduction in prepartion of standard as well
as impurity.
5. reduce maintance standard as well as impurity.
 
Is This Answer Correct ?    0 Yes 1 No
M. Senthil
 
Answer
# 9
relative responce factor is the factor caluecating assay in
chromatography analysis of gc,hplc using deff detectors
(ex:fid,uv etc)
rrf is calulating with comparetively to stadand reference
materials have std potency.
yes it is very important to custrmer side to validated
impurity.
 
Is This Answer Correct ?    13 Yes 16 No
Haran
 

 
 
 
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