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Categories >> Sciences >> Chemistry >> Analytical Chemistry
 
 


 

 
 Organic Chemistry interview questions  Organic Chemistry Interview Questions (228)
 Inorganic Chemistry interview questions  Inorganic Chemistry Interview Questions (96)
 Analytical Chemistry interview questions  Analytical Chemistry Interview Questions (867)
 Physical Chemistry interview questions  Physical Chemistry Interview Questions (57)
 General Chemistry interview questions  General Chemistry Interview Questions (284)
 Chemistry AllOther interview questions  Chemistry AllOther Interview Questions (71)
Question
What is the difference between Capillary coloum and Packed 
coloum.
 Question Submitted By :: Analytical-Chemistry
I also faced this Question!!     Answer Posted By  
 
Answer
# 1
Capillary column : Stationary phase is coated with the
inner wall of the column & it is
having high lenghth and low internal
diameter.

Packed column : Stationary phase is directly coated in
the column & it is having short length
and high internal diameter.
 
Is This Answer Correct ?    48 Yes 11 No
Alpesh Patel
 
Answer
# 2
Capillary column gives better performance as compaired to
pack colums
 
Is This Answer Correct ?    30 Yes 11 No
Mohite Vikas
 
 
 
Answer
# 3
Packed columns are more durable, has higher sample capacity
(Sample load) ,more phase selectivity, and has lower cost.
The disadvantages are larger amounts of bleed, smaller
number of theoretical plates/efficiency (i.e. separating
power for similar compounds is much low) and particle loss
into the detector. So it can not be coupled with MS or other
sensitive detectors.

Capillary columns have the advantage of larger theoretical
plate numbers /efficiency /higher resolution and inertness.
They excel at low ppm to ppt level analysis. They are
limited in phase selectivity options but their low carrier
gas use to the detector and low bleed characteristics allows
Mass Spectroscopy and other sensitive detectors to be used
effectively.
The use of bonded phases permits higher oven temperatures to
be used in applications.So capillary column withstand higher
column oven temperature compared of packed column.
 
Is This Answer Correct ?    7 Yes 0 No
Balla Reddy. P
 
Answer
# 4
Packed columns have higher sample capacity than capillary
columns, although the difference has been greatly reduced by
the large-bore 530m capillaries invented by Agilent.
Improvements in detector sensitivity have also reduced the
need for large samples. The one area in which packed columns
may have an advantage is in analysis of gas samples.

For almost all other samples, capillaries provide much
better efficiency (narrow peaks) which leads to greatly
improved peak separation. In fact, the separating power is
so great that many analyses can be done on surprisingly
short columns in very brief runs. This time saving
translates directly into reduced turnaround time and
increased sample throughput.

For new or updated methods, we recommend capillary columns
unless there is some overwhelming reason for using packed
columns.
 
Is This Answer Correct ?    6 Yes 6 No
Swapnil Borse
 
Answer
# 5
Packed columns: Have high particale size silica (old)

Capilliary columns: Have low particle size silica (new)

Regards
pharmainterviewquestions.blogspot.in
 
Is This Answer Correct ?    3 Yes 3 No
Pharmainterview
 
Answer
# 6
capillary column does nothaving any stationary phase. its
contain length and diameter.it is used for only back
pressure in system calibration.

packed column :its contain stationary phase.
 
Is This Answer Correct ?    7 Yes 33 No
Ksreddy
 

 
 
 
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