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Categories >> Sciences >> Chemistry >> Analytical Chemistry
 
 


 

 
 Organic Chemistry interview questions  Organic Chemistry Interview Questions (222)
 Inorganic Chemistry interview questions  Inorganic Chemistry Interview Questions (96)
 Analytical Chemistry interview questions  Analytical Chemistry Interview Questions (848)
 Physical Chemistry interview questions  Physical Chemistry Interview Questions (57)
 General Chemistry interview questions  General Chemistry Interview Questions (283)
 Chemistry AllOther interview questions  Chemistry AllOther Interview Questions (71)
Question
What is the difference between Chromatograhic Purity And 
Related substances
 Question Submitted By :: Analytical-Chemistry
I also faced this Question!!     Answer Posted By  
 
Answer
# 1
Related substance tests are established after complete
impurity profiling of respective substane where as
Chromatographic purity demonstarte the actual amount of the
substance present with unknown impurities.
 
Is This Answer Correct ?    40 Yes 5 No
Priyesh Mistry
 
Answer
# 2
Related substances means Quantification of Specified
Impurities and unspecified impurities against Reference
standards Exclusively.

Chromatographic Purity means Unspecified impurities by area
noramlisation method.
 
Is This Answer Correct ?    33 Yes 4 No
Bujji Reddy
 
 
 
Answer
# 3
Chromatographic purity means which will give area % of
active ingredients as well as known impurities & unknown
impurities with rference standard.Realated subsances are
may be organic,inorganic and residual solvents(may be
degraents, by
products,contaminents,starting materials,etc)
 
Is This Answer Correct ?    3 Yes 2 No
Basha
 
Answer
# 4
chromatographic purity is calculated by area normalisation
method it gives the percentage of the main product and
related substances by HPLC gives you the Impurity profile
(known + unknown impurity)present in the product.
 
Is This Answer Correct ?    0 Yes 1 No
Sameer Jagtap
 
Answer
# 5
purity test of product is equal to related substance test.purity is product peak area% other than known,unknown impurities area% 
Is This Answer Correct ?    4 Yes 6 No
Chalapathi Rao.n
 
Answer
# 6
In Sample way, Related substance (RS) are associated with
Raw material (API/Excipients)that comes along with desired
raw material either known and/or unknown and Chromatographic
Purity means identified as known and unknown.
 
Is This Answer Correct ?    1 Yes 3 No
Gs
 
Answer
# 7
chromatographic purity means wich is not calculated by
diluted standard.ie,the purity is linear with
concentration.In genearally final drug products calculated
and quantyfied with their diluted standards this is called
as related substances mehod
 
Is This Answer Correct ?    3 Yes 17 No
S Kumar
 
Answer
# 8
chomatographic purity means which will give purity of both
drug substance,known and unknown peaks
related substance means known impurities where as unknown
impurites we can.t quntify
 
Is This Answer Correct ?    5 Yes 22 No
Basha
 

 
 
 
Other Analytical Chemistry Interview Questions
 
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How will you select mobile phase in HPLC Method Development   3
WHAT ARE THE LIMITS FOR UNIFORMITY DOSAGE CONTENT FOR TABLETS AND CAPSULES Micro-Labs 3
why we are adjusting the ph in buffer solution preparation   2
why SGF media used for dissolution . What is the use of it .can we use other media of lower pH instead ot this?   1
What is the SOP for SOP JBCPL 4
only one end point is possible for citric acid and we get 2 end points for di acid why? Reddy-Labs 3
Any molecule is filing for ANDA purpose, what are the dissolution requirements / specifications needed ? Ipca 1
why we want incorporate area of each solution of Intermediate precision and repeatability as well as Accuracy ? What is the use to incorporate area of each solution of Intermediate precision and repeatability as well as Accuracy ?   1
In Analytical method development related substance method when did follow w/w method when did follow area normalisation method   5
How to prepare 10% HCl from 36.5% HCl solution.   2
What is column dead volume? Astron-Research 3
WHAT IS THE DIFFERENT BETWEEN PURITY, POTENCY AND ASSAY Hetero 5
 
For more Analytical Chemistry Interview Questions Click Here 
 
 
 
 
 


   
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