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What is the difference between Chromatograhic Purity And 
Related substances
 Question Submitted By :: Analytical-Chemistry
I also faced this Question!!     Answer Posted By  
# 1
Related substance tests are established after complete
impurity profiling of respective substane where as
Chromatographic purity demonstarte the actual amount of the
substance present with unknown impurities.
Is This Answer Correct ?    42 Yes 5 No
Priyesh Mistry
# 2
Related substances means Quantification of Specified
Impurities and unspecified impurities against Reference
standards Exclusively.

Chromatographic Purity means Unspecified impurities by area
noramlisation method.
Is This Answer Correct ?    34 Yes 5 No
Bujji Reddy
# 3
Chromatographic purity means which will give area % of
active ingredients as well as known impurities & unknown
impurities with rference standard.Realated subsances are
may be organic,inorganic and residual solvents(may be
degraents, by
products,contaminents,starting materials,etc)
Is This Answer Correct ?    3 Yes 3 No
# 4
purity test of product is equal to related substance test.purity is product peak area% other than known,unknown impurities area% 
Is This Answer Correct ?    4 Yes 6 No
Chalapathi Rao.n
# 5
In Sample way, Related substance (RS) are associated with
Raw material (API/Excipients)that comes along with desired
raw material either known and/or unknown and Chromatographic
Purity means identified as known and unknown.
Is This Answer Correct ?    1 Yes 3 No
# 6
chromatographic purity is calculated by area normalisation
method it gives the percentage of the main product and
related substances by HPLC gives you the Impurity profile
(known + unknown impurity)present in the product.
Is This Answer Correct ?    0 Yes 2 No
Sameer Jagtap
# 7
chromatographic purity means wich is not calculated by
diluted,the purity is linear with
concentration.In genearally final drug products calculated
and quantyfied with their diluted standards this is called
as related substances mehod
Is This Answer Correct ?    3 Yes 18 No
S Kumar
# 8
chomatographic purity means which will give purity of both
drug substance,known and unknown peaks
related substance means known impurities where as unknown
impurites we can.t quntify
Is This Answer Correct ?    5 Yes 23 No

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