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Company >> Dr Reddys >> Dr Reddys Questions
 
 Dr Reddys technical test questions  Dr-Reddys Technical Test Questions (2)  Dr Reddys interview questions  Dr-Reddys Interview Questions (20)
 
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Question   Why using Holmium oxide in UV calibration Rank Answer Posted By  
 Interview Question Submitted By :: Guest
I also faced this Question!!   © ALL Interview .com
Answer
For control of wavelength  holmium oxide is used because of 
the stability of the solution and it will cover UV-VIS 
range.
241,287,361,536nm
 
3 Ramu
 
 
Answer
B'coz of it show maximum lambda max in UV-VIS range
 
0 Bhalchandra Farde Anuh Pharma
 
 
Answer
HOLMIUM oXIDE GIVE THE DISTINCT WAVELENGTH IN UV VIS RANGE.
 
0 Sachin.bedwal
 
 
 
Answer
because of it is a stable and it will cover broad range
 
0 Anand Patel
 
 
Answer
  
 
0 ANALYTICALSTUDENT
 
 
Answer
Holmium oxide is stable and it will give absorbance in both 
UV and Visible region(200-600 SCANNING RANGE)and give 
absorbance at 241.15,287.15,361.5,536.3
 
0 Rk
 
 
Answer
Because Holmium perchlorate soluition shows multiple distinctive wavelength for UV and visible region.
 
0 Kishor Raut
 
 
Question   What is the formula for Tapdensity / Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
Tap density=Weight of the sample/Volume of the silinder 
after tapping the sample
 
0 Ramus
 
 
Answer
Tap density=Weight of the sample/Volume of the sample in the
cylinder
 
0 Rc
[Vimta Labs Ltd]
 
 
Answer
Tapped Density- W/V
 where W is weight of sample
       V is final tapped volume
this is as per USP
 
0 Murari
[Vimta Labs Ltd]
 
 
Answer
density means mass/volume

 tapped density = Wt. of sample taken / volume of sample in 
the cylinder after tapping
 
0 Reshma Ghadge
[Vimta Labs Ltd]
 
 
Answer
Weight of the substance
Tapped density  =   --------------------------
               Volume of the substance (after tapping)      
            
    The density of solids normally expressed in g per cm3 
and liquids is normally expressed in g per ml. However 
because powder volumes are measured in cylinders graduated 
in ml, tapped density is expressed in g/ml.
 
0 Bhupalreddy
[Vimta Labs Ltd]
 
 
Answer
weight of sample/volume of sample
 
0 Divya
[Vimta Labs Ltd]
 
 
Question   What is the Defination of Tapdensity ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
Tapdensity means after tapping what volume we get.

Tapdensity = weight/after tapping volume which we get.
Tapdensity is greater than untapdensity.
 
0 Tushar
 
 
Answer
Tap density =Weight of the sample(how much you are 
weighing)/After Tapping the sample (you considered only in 
volumes).
 
0 Ramus
[Vimta Labs Ltd]
 
 
Answer
Tapped density = Weight of sample taken in g / Volume of 
the sample in mL after tapping specified strockes. 
The unit of the Bulk density & tapped density is g/mL
 
0 Alpesh Patel (jbcpl)
[Vimta Labs Ltd]
 
 
Answer
Tap density is a device in which mechanically tapping of a
measuring cylinder with the powdered sample . with the
formula g\ml

m\vf
 
0 Viji
[Vimta Labs Ltd]
 
 
Question   What is the defination of Bulk density? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
Bulkdensity means intial volume when we are taken in 
measuring cylinder i.e., Bulk density=Mass/Volume
 
0 Devi
 
 
Answer
Bulkdensity means initial volume of before tapping
Bulk density=wt/vol
 
0 Manikanta
[Vimta Labs Ltd]
 
 
Answer
Bulk density means the intrlocular spaces between the
particals which are voided after tapping.i.e initial
volume-final volume after taping
 
0 Ashok Kumar
[Vimta Labs Ltd]
 
 
Question   Whya the need of Specificity to do in Analytical Method Validation ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
Specificity is proves that your method of analysis is
capable or not to resolve the all know impurities, unknown
impurities, degradation product and matrix compound by
proving the peak purity and also prove that all known
impurity are well separate from each other.
 
4 M
 
 
Answer
The specificity of an analytical method is basically to

1) To prove the stability indicating ability of the method

2)To identify the possible degradation of the molecule

3)To determine the type of degradation the molecule is
susceptible to

4)To prove the mass balance 

5)To know the various degradation path ways of molecule
 
5 Rc
[Vimta Labs Ltd]
 
 
Answer
specipicity is do to known whether any excipient interfere 
with our analyte drug peak resolusion .
 
0 Nitin
[Vimta Labs Ltd]
 
 
Answer
IN SPECIFICITY WE HAVE TO IDENTYFY THE CONCENTRAION OF 
SPECIFIC COMPONENT IN ENTIRE MIXTURE
 
0 Sachin.bedwal
[Vimta Labs Ltd]
 
 
Question   What is Specificity ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
The specificity of the method was determined by analyzing 
standard drug &test samples.the purity of the drug 
determined by comparing Three regions i.e. peak start peak 
apex & peak end.
 
0 Vaishali Musale
 
 
Answer
this parameter is used to check the purity's of sample and impurities which we are used in validation,Retention time identification,check the separation of impurities and also used to calculation of RRT AND RRf's
 
0 Phanindra
[Vimta Labs Ltd]
 
 
Answer
Specificity determines the consider peak is single or it co-
eluting with another peak with same retention time. And 
peak purity should be pass for comsider peak.
There is no interference of balnk and placebo peaks with 
Active peak and impurity peaks. also
 
0 Vidyaevuri
[Vimta Labs Ltd]
 
 
Answer
Specificity is one of the experiment name during method 
validation. As the name suggests, this exp is done to find 
how specific the method is for the analytes being analysed. 

PDA detector is used to ensure the absence of co-elusion 
and ultimately the specificity.
 
0 Sham
[Vimta Labs Ltd]
 
 
Answer
Specificity is the ability to assess unequivocally the 
analyte in the presence of components which might be 
expected to be present. These might include impurities, 
degradants, complex matrices, etc.
 
0 Subash
[Vimta Labs Ltd]
 
 
Question   what buffer you can select for acidic nature analyte and how ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
Selection of buffer pH is depend on the pKa Value of
compound as you say the nature of compound is acidic so i
will prefer the acidic buffer near pH about +-1 of pKa value
of analyte and the buffer with acidic pH range i prefer
phospahte buffer because it is depend the buffer pKa also.
 
0 M
 
 
Answer
For an acidic nature compound u should use only  acid pH 
buffers only why because acid compounds are showing more 
hydrofobicity in acid pH, if the sample is having more 
hydrofobicity it retains on column and it gives good peak 
shape and advisable retention time,
if we do acid samples in basic pH buffers the sample 
undergoes ionisation meanwhile increases the hydrophilic 
nature dueto this hydrophilic nature the sample not retains 
on the column.  u must select a acid pH to analyse the acid 
samples.
 
0 Shyam Kumar
[Vimta Labs Ltd]
 
 
Question   How you can calculate pKa ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
0.529/N*Log[H+]OH[-]
 
0 Mu
 
 
Answer
-log10[Ka] =pKa where Ka is dissociation constant and can 
be calculated by using formula Ka = [H+][B-]/[HB]
 
0 S Rampal
[Vimta Labs Ltd]
 
 
Answer
Carry out acid-base titration and note down the 
readings.Plot a graph of pH nersus volume of titrant added. 
Locate the equivalence point. Compute the volume exactly 
half the equivalent point and from this volume 
corresponding pH is nothing but pKa.
 
0 Pratap Rasam
[Vimta Labs Ltd]
 
 
Answer
pKa = pH-iog(conjugate base)/conjugate acid).
 
0 Sachin.bedwal
[Vimta Labs Ltd]
 
 
Answer
FOR PKa DTETERMINATION DIFFERENT METHOD USED AS FOLLOWS

1.SPECTROSCOPY METHOD
2. POTENTIOMETRIC METHOD
3. CAPILLARY CHROMATOGRAPHIC METHOD
 
0 Ganesh Bhavar
[Vimta Labs Ltd]
 
 
Answer
The equation for pKa is this:
 
Presuppose you have a compound HX is 

HX --> H+ + X-
 pKa = -log Ka

To find the Ka:
Ka = [H+] x [X-]/[HX]
 
Ka (is dissociation constant) is always products over 
reactants.
 
0 Bhupalreddy
[Vimta Labs Ltd]
 
 
Question   what is pKa ? Rank Answer Posted By  
 Interview Question Submitted By :: Ramjetti
I also faced this Question!!   © ALL Interview .com
Answer
pka = -log (H+ + oH- /H2o)
 
0 Dr.srinivas
 
 
Answer
pKa means negetive log of dissociation constant
 
0 Yojana
[Vimta Labs Ltd]
 
 
Answer
Ability to know strength of the solution(acidic/basic)
 
0 Vijayalakshmi
[Vimta Labs Ltd]
 
 
Answer
it can be determine the by using the handorsons equ 

                or 
 by using automatic titrator method
 
0 Pavan
[Vimta Labs Ltd]
 
 
Answer
Half equivalence point.
 
0 Prasad
[Vimta Labs Ltd]
 
 
Answer
At pKa half of the compound is in acid form and remaining 
half in the base form. Also, it is nothing but the pH at 
half neutralization. Smaller the value of pKa stronger the 
acid and vise-versa. It is the inverse of dissociation 
constant K.
 
0 Pratap Rasam
[Vimta Labs Ltd]
 
 
Answer
POTENCY OF HYDROGEN IONS
 
0 Madhav
[Vimta Labs Ltd]
 
 
Answer
acid is half neutralized
 
0 Nitin
[Vimta Labs Ltd]
 
 
Answer
pka=inderectly proposanal of the acidity constant
 
0 Kalyan(neuland)
[Vimta Labs Ltd]
 
 
Answer
Definition of pKa :
(pK for short). The negative logarithm of the acid dissociation constant, Ka.

Just like the pH, the pKa tells you of the acid or basic properties of a substance.
pKa <2 means strong acid
pKa >2 but <7 means weak acid
pKa >7 but <10 means weak base
pKa >10 means strong base
 
0 Nishabd
[Vimta Labs Ltd]
 
 
Question   In Dry powder inhalation Andersen casacde impacor for FPF performing in that we adjusting 60LPM/MIN and time 4second ,why? Explain Rank Answer Posted By  
 Interview Question Submitted By :: Audumbar
I also faced this Question!!   © ALL Interview .com
Answer
As per USP guideline the normal healthy person is having 
Lungs Air volume Capacity is 4lit.  and when we measure the 
air flow at that litre,so flow metre will show the air flow 
60.
 thus it mean 1 second per 1 Litre, so for the 4 litre  is 
required 4 second , that's why we performed the Andeson 
Cascade at 60LPM/MIN and  at 4 second
 
0 Rajnikant
 
 
Question   what is sink condition in Dissolution? Rank Answer Posted By  
 Interview Question Submitted By :: Audumbar
I also faced this Question!!   © ALL Interview .com
Answer
In general the dissolution medium volume should be 3-10 
times the saturation solubulity of the drug. Sink 
conditions means thd drug which goes in to the solution is 
not effected by the drug which not dissolved.
 
4 Ram
 
 
Answer
it is a condition at which the concentration of drug is
maintain in blood after administration of drug due to
continuous flow of blood
 
0 Hariram
 
 
Answer
In sink condition, the volume of Medium is more than 5-10 folds of its saturation point & in anyway it Drug will not reach to its saturation point.
 
5 Indra Kumar Gupta
 
 
Answer
how much drug absorb its eliminated in same amount
 
0 Honey
 
 
Answer
The concentration of drug at absorption site i.e.,GIT is more than in plasma level.....
It follows first order reaction(non linear graph)
 
5 N Bharth Kumar
 
 
Answer
accordng to ficks first low c git is zero compare to c plasma .if have zero condition disslution  is high
 
0 Ranjith
 
 
Answer
it is the condition at which the concentration of drug in 
git is maintain greater then that of in plasma.
 
0 Pankaj Kumar
 
 
Answer
One of the requirements to conduct an appropriate drug 
dissolution test is to use a sufficient volume of 
dissolution medium, which should be able to dissolve the 
expected amount of drug released from a product. This 
ability of the medium to dissolve the expected amount of 
drug is known as a “sink condition”.It is important to note 
that a dissolution test should not be conducted in a volume 
of the medium which would not dissolve the expected amount 
of the drug completely and freely.
 
0 Ganesh Parsewar
 
 
Answer
which should be able to dissolve the expected amount of drug released from a product. This ability of the medium to dissolve the expected amount of drug is known as a “sink condition"
 
0 K.gopal Rao
 
 
Question   Why we are using only KBr in IR spectrometer why not KCl Rank Answer Posted By  
 Interview Question Submitted By :: Ramana
I also faced this Question!!   © ALL Interview .com
Answer
KBr gives better resolution than KCL...
 
2 Keshava
 
 
Answer
KBr could not have any absorbance in IR range,but Kcl have
absorbance
 
0 G.balaji
 
 
Answer
KBr shows Absorbance in  2.4 -16 MICROMETER of IR REGION.
 While other compound shows Transmittance in 2.4 -16
MICROMETER of IR REGION. & hence resolution is not achieved .

& for the purpose of resolution & background correction KBr
is the best option.


Ramkrishna thakare -------sandoz
 
0 Ramkrishna Thakare
 
 
Answer
KBr could not have any absorbance in IR range,but Kcl have
absorbance and itis easily miscible with other samples for
analysis it is cheep and best available in market
 
0 Ravi.a
 
 
Answer
Actuly alkli halide are used for this perpose..because they
are inert and could not have any absorbance in IR range..so
we can use kcl instead of kBr...
 
0 Paresh Jobanputtra
 
 
Answer
we can use both kbr & kcl because they could not have any 
absorbance in the ir region.

mostly for the compound having cloride group the kcl is 
better option than kbr.
 
5 Parag Parekh
 
 
Answer
KBR can not absorbance in IR region. and it is a primary standard.
KBR does not catch the moisture easy better than KCL 
KBR STABLE also
 
0 Ramalaxmi Ch
 
 
Answer
KBr gives better resolution than KCL...
KBr could not have any absorbance in IR range
Kbr coild not interference with other compounds in IR Range.
 
0 Manoj Patel
 
 
Answer
KBr is optically transparent over the range of wavelengths 
in the wavelength range of IR analysis. This means KBr does 
not have any absorbance in IR region.
 
0 Jayalakshmi
 
 
Question   how FTIR calibration Doing? Rank Answer Posted By  
 Interview Question Submitted By :: Audumbar
I also faced this Question!!   © ALL Interview .com
Answer
with polystyrene film
wave number check and resolution as per BP
 
0 Murugesan
 
 
Answer
1)with polystyrene film
 2)wave number check
3 ) resolution. 
4) energy efficiency.



Ramkrishna thakare --------Sandoz
 
0 Ramkrishna Thakare
 
 
Answer
Doing the calibration of FT-IR using Polystyrene film.You 
have to do the three things in the calibration procrdure.
1)Verification of Wave number scale
2)Control of resolution between two types you have to check
a)Transmission minimum at 1583 
  Transmission maximum at 1589 
b)Transmission minimum at 2849.5
  Transmission maximum at 2870
 
0 Ramu
 
 
Answer
FTIR calibration with Polystyrene film
Check calibration are given the parameters
1) Wave number accuracy
2) Wave number repeatability
3) % Transmitance
4) Resolution
 
0 Gln Reddy
 
 
Question   What is difference between method validation and Verification? Rank Answer Posted By  
 Interview Question Submitted By :: Audumbar
I also faced this Question!!   © ALL Interview .com
Answer
Method validation- is a type of validation .the validation 
in which we adopt method
Verification
general idendification test
 
0 Ankur Sharma
 
 
Answer
method validation - Is highly controlled condition which
render high  degree of assurance for intended use.  


Verification - high  degree of assurance  to verify 



Ramkrishna thakare -------- sandoz
 
0 Ramkrishna Thakare
 
 
Answer
Validation is the documented evidence about any 
method/process or other by which we establish the method 
applicable is produce consistant result and so OK for its 
intended use.
Verification:It is high degree of assurance about 
comparison to the standard values.
 
0 Kishor Solanke (alkem)
 
 
 
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